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Wt p53 function is regulated bycomplex combinations of post-translational modi?cations including phosphoryla-tion, acetylation, ubiquitination, methylation, sumoylation and neddylation [ 24 ].On the contrary, we know very little about the post-translational modi? cations pres-ent in mutant p53 and the enzymes responsible for them. Her Clinical Dementia Rating (CDR) was0.5; Clock Drawing Test Score (CDT) was 3/ 3 ADL 12/12,IADL 15/16.

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Simple carbohydrates, such as found in fruit juice, are sugarwith a simple structure that raises the blood glucose level andcan be converted quickly into energy. Unlike cells undergoing necrosis, which swell andrelease their cellular contents, apoptotic cells generallyretain plasma membrane integrity and shrink, resulting incondensed cytoplasm and dense chromatin in the nucleus.Apoptosis is often a slower process than necrosis

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